An antidepressant is a medication used primarily in the treatment of depression. paxil Depression can occur if some of the chemicals called neurotransmitters in the brain are not functioning effectively. endep There are three specific chemicals that can affect a person's mood zyban sr Antidepressants affect one or more of these chemicals in different ways to help stabilize the chemical imbalance often seen in depression. ibuprofen zyban sr seroquel