Press alt+r to access the script menu. Then goto "remote" then on file "new".
Add this in the new remote:

menu nicklist {
  Mute 
  ..Mute { 
    /mode $chan -v $$1
    /mode $chan +b ~q: $+ $address($$1,2)
    /notice $$1 You have been muted on $chan
  }
  ..Unmute {
    /mode $chan -v $$1
    /mode $chan -b ~q: $+ $address($$1,2)
    /notice $$1 You can now speak on $chan
  }
  ..Mute 1m {
    /mode $chan -v $$1
    /mode $chan +b ~q: $+ $address($$1,2)
    /notice $$1 You have been muted on $chan for 1 min.
    /timer 0 60 /mode $chan -b ~q: $+ $address($$1,2)
  }
  ..Mute 5m {
    /mode $chan -v $$1
    /mode $chan +b ~q: $+ $address($$1,2)
    /notice $$1 You have been muted on $chan for 5 mins.
    /timer 0 300 /mode $chan -b ~q: $+ $address($$1,2)
  }
}


Goto file, "save". Close and rightclick a user on the userlist =]