From models.py:

class emailusername(models.Model):
    """                                                                                    
    Store each username just once along with an integer ID which is                        
    automatically created by the ORM.                                                      
    """

    username = models.CharField(max_length=64);

class emaildomain(models.Model):
    """                                                                                    
    Store each domain just once along with an integer ID which is                          
    automatically created by the ORM.                                                      
    """

    domain = models.CharField(max_length=64);

class emailaddress(models.Model):
    """                                                                                    
    Store each email address as a combination of integer@integer                           
    foreign key relationships to the emailusername and emaildomain                         
    classes. Django automatically links the integer ID columns for us.                     
                                                                                           
    This is much more space efficient and faster for lookup than                           
    storing each individual email address as a string.                                     
    """

    username = models.ForeignKey('emailusername')
    domain   = models.ForeignKey('emaildomain')

from parsemail.py which imports models from models.py:

    (userto,domainto)         = parseaddr(mail['To'])[1].split('@')
    newemailaddress           = emailaddress()
    newemailusername          = emailusername()
    newemaildomain            = emaildomain()
    newemailusername.username = userto
    newemaildomain.domain     = domainto
    newemaildomain.save()
    newemailusername.save()
    newemailaddress.username  = newemailusername
    newemaildomain.domain     = newemaildomain
    newemailaddress.save()