First System:
[root@testbox ~]# prelink -y /bin/ls > /bin/ls.org
[root@testbox ~]# md5sum /bin/ls
71ab9695aa71067a3a24cd46a9f34e97  /bin/ls
[root@testbox ~]# md5sum /bin/ls.org 
9b6a112bdfec414171e85695dcb6412b  /bin/ls.org


Second System:
[root@web85 ~]# prelink -y /bin/ls > /bin/ls.org
[root@web85 ~]# md5sum /bin/ls
d355f25ae401c7abd53314da3425c293  /bin/ls
[root@web85 ~]# md5sum /bin/ls.org 
9b6a112bdfec414171e85695dcb6412b  /bin/ls.org

Notice how both systems after prelinking has been removed have the same md5check sums:

testbox: 9b6a112bdfec414171e85695dcb6412b  /bin/ls.org
web85:   9b6a112bdfec414171e85695dcb6412b  /bin/ls.org