Steps to adding a host:

1) Add block to /usr/local/etc/lighttpd-sites.conf
$HTTP["host"] == "djangosource.com" {
        server.document-root = "/home/djangoso",
        alias.url = (
                "/media/" => server.document-root+"/media/",
        ),
        url.rewrite-once = (
                "^(/media.*)$" => "$1",
                "^(/.*)$" => "/django.fcgi$1"
        ),
	fastcgi.server = (
		"/django.fcgi" =>
		( "localhost" =>
			(
				"socket" =>  server.document-root+"/django-fcgi.socket"
			)
		)
	)
}

2) give them a new project, named www
django-admin.py startproject

3) setup their database, based on their request (for now, only mysql), and fill their premade settings.py with it
DATABASE_ENGINE = ''           # 'postgresql', 'mysql', 'sqlite3' or 'ado_mssql'.
DATABASE_NAME = ''             # Or path to database file if using sqlite3.
DATABASE_USER = ''             # Not used with sqlite3.
DATABASE_PASSWORD = ''         # Not used with sqlite3.
DATABASE_HOST = ''             # Set to empty string for localhost. Not used with sqlite3.
DATABASE_PORT = ''             # Set to empty string for default. Not used with sqlite3.

4) set their media root and media url in their premade settings.py
# Absolute path to the directory that holds media.
# Example: "/home/media/media.lawrence.com/"
MEDIA_ROOT = ''

# URL that handles the media served from MEDIA_ROOT.
# Example: "http://media.lawrence.com"
MEDIA_URL = ''

5) set their template path in their premade settings.py
TEMPLATE_DIRS = (
    # Put strings here, like "/home/html/django_templates" or "C:/www/django/templates".
    # Always use forward slashes, even on Windows.
    # Don't forget to use absolute paths, not relative paths.
)

6) give control to start/stop their webserver
./manage.py runfcgi method=prefork socket=/home/djangoso/django-fcgi.socket pidfile=django.pid