Excel.Application ThisApp = new Excel.Application(); ThisApp.Workbooks.Add(Type.Missing); Excel.Workbook wb = ThisApp.ActiveWorkbook; Excel.Worksheet ws = (Excel.Worksheet)wb.Worksheets[1]; ((Excel.Range)ws.Cells[1, 1]).Value2 = ""; ThisApp.ActiveWorkbook.SaveAs(filename, Excel.XlFileFormat.xlExcel9795, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Excel.XlSaveAsAccessMode.xlExclusive, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing); ThisApp.Quit(); System.Runtime.InteropServices.Marshal.ReleaseComObject(ThisApp);