$ winedbg --gdb --no-start notepad.exe
0010:0011: create process 'C:\windows\system32\notepad.exe'/0x110660 @0x7ec859b0 (0<0>)
0010:0011: create thread I @0x7ec859b0
$ winedbg notepad.exe
WineDbg starting on pid 0010
0x7ee80da9: movl        %edi,0x0(%esp)
Wine-dbg>cont
couldn't load main module (2)
0x7ee69da9: movl        %edi,0x0(%esp)
Wine-dbg>cont

----

At this point notepad.exe starts running.

I quit notepad...

----
Process of pid=0010 has terminated
Process of pid=0012 has terminated
Wine-dbg>